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NRP2抗體

抗原
Neuropilin 2 (NRP2)
別名 NP2, NPN2, PRO2714, VEGF165R2, 1110048P06Rik, Np-2, Np2, Npn-2, Npn2, neuropilin-2
抗原表位
其他選擇 AA 1-855
C-Term(9),AA 1-855 (7),AA 805-835 (7),Internal Region (5),AA 621-715 (2),AA 798-827 (2),N-Term (2),AA 1-926 (1),AA 324-373 (1),AA 432-547 (1),AA 621-716 (1),AA 652-858 (1),Met373 (1)
適用
其他選擇 Human
Human(35),Rat ((Rattus)) (9),Murine (8),Bovine (1),Dog (Canine) (1)
宿主
其他選擇 Rabbit
Rabbit(28),Mouse (7),Chicken (1)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
PE(3),APC (1),Alkaline Phosphatase (AP) (1),Biotin (1),FITC (1),HRP (1)
zui低檢測濃度 0.6 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(29),ELISA (24),Immunohistochemistry (IHC) (5),Flow Cytometry (FACS) (2),Immunoassay (IA) (1),Immunocytochemistry (ICC) (1),Immunohistochemistry (Frozen Sections) (IHC (fro)) (1),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1)
[Pubmed] 7 references available
規(guī)格 100 μg
發(fā)貨至 中國 (更改)

NRP2抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

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亞型 IgG
特異性 Human NRP2 / Neurophilin-2
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human NRP2 extracellular domain (rhNRP2, aa 1-855, NP_003863.2). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標(biāo)詳細情況

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目標(biāo)詳細情況

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別名 NRP2
背景 Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classIII semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.
NCBI Accession NP_003863.2
研究領(lǐng)域 Neurology

使用細節(jié)

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使用細節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human NRP2. The detection limit for Human NRP2 is approximay 0.6 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
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