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IL17RA抗體

抗原
Interleukin 17 Receptor A (IL17RA)
別名 IL17R, CANDF5, CD217, CDw217, IL-17RA, hIL-17R, Il17r, AW538159, Cdw217, VDw217
抗原表位
其他選擇 AA 1-320
Internal Region(12),C-Term (8),AA 1-320 (7),AA 720-747 (7),Extracellular Domain (3),AA 1-322 (2),AA 32-322 (2),AA 33-320 (2),AA 721-747 (2),AA 1-866 (1),AA 117-166 (1),AA 33-172 (1),AA 377-534 (1),AA 58-302 (1),AA 590-848 (1),AA 802-866 (1),AA 97-115 (1),N-Term (1)
適用
其他選擇 Human
Murine(48),Human (42),Rat ((Rattus)) (19)
宿主
其他選擇 Mouse
Rabbit(56),Goat (7),Mouse (6),Rat (3)
克隆類型 (克隆位點)
單克隆 (8E6B9F4)
標記
其他選擇 非結(jié)合性
Biotin(3),FITC (3),APC (2),HRP (2),PE (2),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),CF (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1)
應(yīng)用范圍
其他選擇 Western Blotting (WB)
Western Blotting (WB)(47),ELISA (40),Flow Cytometry (FACS) (15),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8),Immunocytochemistry (ICC) (3),Immunohistochemistry (Frozen Sections) (IHC (fro)) (3),Enzyme Immunoassay (EIA) (2),Immunohistochemistry (IHC) (2),Immunoassay (IA) (1),Immunofluorescence (IF) (1),Neutralization (Neut) (1)
規(guī)格 50 μg
發(fā)貨至 中國 (更改)

IL17RA抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

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免疫原 Recombinant human IL17RA protein
克隆位點 8E6B9F4
亞型 IgG1
特異性 Human IL17RA / CD217
交叉反應(yīng) （詳細） No cross-reactivity with human cell lysate (293 cell line) in WB and ELISA
產(chǎn)品特性 This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human IL17RA ( rh IL17RA , NP_055154.3 , Met 1 - Trp 320 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標詳細情況

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目標詳細情況

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別名 IL17RA
背景 IL17RA ( Interleukin 17 receptor A ), also known as IL17R and CDw217, is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A (IL17A). IL17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL17A binds to a type I cell surface receptor called IL17R of which there are at least three variants IL17RA, IL17RB, and IL17RC. IL17RA is a widely expressed glycoprotein that plays a central role in inflammatory responses. IL17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. Human IL17RA is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of human IL17RA is 69% identical to the mouse IL17R. Within the extracellular domain, human IL17RA shares 72% aa sequence identity with mouse and rat IL17RA. IL17RA associates with IL17RC to form a signaling receptor complex for IL17 and IL17F. Ligand and IL17RA ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines.
NCBI Accession NP_055154.3

使用細節(jié)

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使用細節(jié)

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應(yīng)用備注 Western blot - WB: 10-20 μg/mL
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
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