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UPK3A抗體

抗原
Uroplakin 3A (UPK3A)
別名 UPK3A, Upk3, upk3, upiii, MGC75921, UPIII, UP3A, UPIIIA, UPK3, UP3a, 1110017C07Rik
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(31),Rat ((Rattus)) (13),Murine (11),Bovine (9),Pig (Porcine) (2)
宿主
其他選擇 Rabbit
Rabbit(28),Mouse (10)
克隆類(lèi)型
多克隆
標(biāo)記
其他選擇 Cy5
Alexa Fluor 350(1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Biotin (1),Cy3 (1),Cy5.5 (1),Cy7 (1),FITC (1),HRP (1)
應(yīng)用范圍
其他選擇 Immunofluorescence (Paraffin-embedded Sections) (IF (p))
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))(27),Western Blotting (WB) (17),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (9),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (8),Immunohistochemistry (Frozen Sections) (IHC (fro)) (3),Immunohistochemistry (IHC) (2)
規(guī)格 100 μL
發(fā)貨至 中國(guó) (更改)

UPK3A抗體

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產(chǎn)品細(xì)節(jié)

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免疫原 KLH conjugated synthetic peptide derived from human UPK3A
亞型 IgG
交叉反應(yīng) Murine, Rat ((Rattus))
純化方法 purified by Protein A

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目標(biāo)詳細(xì)情況

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別名 UPK3A
背景 The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response.

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應(yīng)用備注 IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.
說(shuō)明

Excitation / Emission wavelength: 652nm / 670nm

限制 For Research Use only

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狀態(tài) Liquid
濃度 1 μg/μL
緩沖液 Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
儲(chǔ)存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
儲(chǔ)存條件 4 °C

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