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HPSE抗體

抗原
Heparanase (HPSE)
別名 im:7144134, hpa, hpa1, hpr1, hpse1, hse1, HPSE, HPA, HPA1, HPR1, HPSE1, HSE1, Hpa, Hpr1, Hep
適用
其他選擇 Human, Murine, Rat ((Rattus)), Dog (Canine), Pig (Porcine), Bovine
Human(98),Murine (41),Rat ((Rattus)) (35),Dog (Canine) (23),Pig (Porcine) (23),Bovine (11)
宿主
其他選擇 Rabbit
Rabbit(96),Mouse (14)
克隆類型
多克隆
標(biāo)記
其他選擇 Cy5
Biotin(11),HRP (5),FITC (4),APC (2),Alexa Fluor 350 (2),Alexa Fluor 488 (2),Alexa Fluor 555 (2),Alexa Fluor 647 (2),Alkaline Phosphatase (AP) (2),Cy3 (2),Cy5.5 (2),Cy7 (2),PE (2),Cy5 (1),DyLight 488 (1),DyLight 550 (1),DyLight 650 (1),Magnetic Particles (1),Sepharose (1)
應(yīng)用范圍
其他選擇 Immunofluorescence (Paraffin-embedded Sections) (IF (p))
Western Blotting (WB)(74),ELISA (44),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (25),Immunohistochemistry (IHC) (23),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (19),Immunohistochemistry (Frozen Sections) (IHC (fro)) (13),Immunocytochemistry (ICC) (12),Flow Cytometry (FACS) (6),Immunoprecipitation (IP) (4),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (2),Enzyme Immunoassay (EIA) (1)
規(guī)格 100 μL
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HPSE抗體

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產(chǎn)品細(xì)節(jié)

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免疫原 KLH conjugated synthetic peptide derived from human Heparanase
亞型 IgG
交叉反應(yīng) Murine, Rat ((Rattus)), Dog (Canine), Pig (Porcine), Bovine
純化方法 purified by Protein A

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目標(biāo)詳細(xì)情況

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別名 Heparanase
背景 Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasations of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and an 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in plaets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival.

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應(yīng)用備注 IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.
說明

Excitation / Emission wavelength: 652nm / 670nm

限制 For Research Use only

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狀態(tài) Liquid
濃度 1 μg/μL
緩沖液 Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
儲存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
儲存條件 4 °C

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