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MC4R 抗體

抗原
Melanocortin 4 Receptor (MC4R)
別名 zMC4, si:dkey-151m6.62, mc4r, MC4R, LOC100218148, Mc4-r
抗原表位
其他選擇 N-Term
N-Term(15),AA 1-50 (13),AA 306-332 (10),AA 6-20 (2),C-Term (2),Extracellular Loop (2),AA 1-45 (1),AA 10-60 (1),AA 21-33 (1),AA 281-330 (1),Cytoplasmic Domain (1),Glu315 (1)
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(55),Rat ((Rattus)) (35),Murine (32),Horse (Equine) (1)
宿主
其他選擇 Rabbit
Rabbit(60),Goat (2)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
FITC(4),Biotin (3),CF (2),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),HRP (1),PE (1)
應(yīng)用范圍
其他選擇 Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Western Blotting (WB)(32),ELISA (29),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (14),Immunohistochemistry (IHC) (13),Flow Cytometry (FACS) (11),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunocytochemistry (ICC) (3),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (3),Dot Blot (DB) (1),Immunofluorescence (IF) (1)
[Pubmed] 1 reference available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

MC4R 抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

顯示 隱藏
免疫原 MC4R antibody was raised against a 19 amino acid peptide near the amino terminus of human MC4R.
亞型 IgG
特異性 This antibody detects MC4-R.
交叉反應(yīng) （詳細） Species reactivity (tested):Human, mouse, rat
純化方法 Peptide affinity chromatography

目標(biāo)詳細情況

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目標(biāo)詳細情況

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別名 MC4-R
背景 The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity, activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.Synonyms: MC4R, Melanocortin receptor 4
基因ID 4160
NCBI Accession NP_005903
UniProt P32245
研究領(lǐng)域 Receptors

使用細節(jié)

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使用細節(jié)

顯示 隱藏
應(yīng)用備注 ELISA. Western blot: 1 - 2?μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS containing 0.02?% sodium azide
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項 Avoid repeated freezing and thawing.
儲存條件 4 °C/-20 °C

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