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BBC3 抗體

抗原
BCL2 Binding Component 3 (BBC3)
別名 BBC3, Puma, JFY-1, JFY1, PUMA, PUMA/JFY1
抗原表位
其他選擇 N-Term
C-Term(66),N-Term (39),AA 76-170 (12),AA 150-193 (6),AA 108-137 (5),Internal Region (4),AA 109-137 (2),AA 119-154 (2),BH3 Domain (2),Center (2),AA 120-169 (1),AA 130-193 (1),AA 2-16 (1),Arg169 (1)
適用
其他選擇 Human
Human(206),Murine (54),Rat ((Rattus)) (54),Dog (Canine) (12),Pig (Porcine) (12),Zebrafish (3)
宿主
其他選擇 Rabbit
Rabbit(170),Mouse (40),Goat (4)
克隆類型
多克隆
標記
其他選擇 非結合性
FITC(5),APC (4),Alkaline Phosphatase (AP) (4),Biotin (4),HRP (4),PE (4),Atto 390 (2),Atto 488 (2),Atto 565 (2),Atto 594 (2),Atto 633 (2),Atto 655 (2),Atto 680 (2),Atto 700 (2),PE-Atto 594 (2),PerCP (2),Streptavidin (2),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),DyLight 488 (1),DyLight 550 (1),DyLight 650 (1),Magnetic Particles (1),Sepharose (1)
應用范圍
其他選擇 Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Western Blotting (WB)(199),ELISA (60),Immunohistochemistry (IHC) (45),Immunocytochemistry (ICC) (33),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (24),Immunofluorescence (IF) (20),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Enzyme Immunoassay (EIA) (8),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (6),Flow Cytometry (FACS) (5),Immunoprecipitation (IP) (5),Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (2),Immunohistochemistry (Frozen Sections) (IHC (fro)) (2)
[Pubmed] 3 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

BBC3 抗體

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產品細節(jié)

顯示 隱藏
免疫原 Synthetic peptide corresponding to 14 amino acids near the amino terminus of Human PUMA-alpha. .Remarks: This sequence is identical between alpha and beta forms of the PUMA proteins.
亞型 IgG
特異性 This antibody detects PUMA at N-term.
交叉反應 （詳細） Species reactivity (tested):Human.
純化方法 Peptide Affinity Chromatography

目標詳細情況

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別名 PUMA
背景 Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.Synonyms: BBC3, Bcl-2-binding component 3, JFY-1, p53 up-regulated modulator of apoptosis
基因ID 27113
NCBI Accession NP_055232
UniProt Q9BXH1
研究領域 Cancer, Apoptosis/Necrosis, Metabolism

使用細節(jié)

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使用細節(jié)

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應用備注 ELISA. Western blot: 2 to 4?μg/mL, K562 cell lysate can be used as a positive control and a band atapproximay 23 kDa can be detected. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS, 0.02?% Sodium Azide
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項 Avoid repeated freezing and thawing.
儲存條件 4 °C/-20 °C

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