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Smad蛋白相互作用蛋白1抗體

英文名稱 SIP1
中文名稱 Smad蛋白相互作用蛋白1抗體
別    名 Smad Interacting Protein 1 SIP 1; SIP1 SIP-1; Smad-interacting protein 1; SMADIP 1; SMADIP1; ZEB 2; ZEB2; ZEB2_HUMAN; Zfhx1b; ZFHX1B protein; Zfx1b; Zinc finger E box binding protein 2; Zinc finger E-box-binding homeobox 2; Zinc finger homeobox 1b; zinc finger homeobox protein 1; Zinc finger homeobox protein 1b.

說 明 書 0.1ml  0.2ml  
研究領域 心血管  細胞生物  發(fā)育生物學  神經(jīng)生物學  干細胞  細胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Horse, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 136kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGF∫ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.

Function:
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.xy-10036R    REG4再生基因蛋白4抗體
xy-10055R    RIP1受體相互作用蛋白激酶1抗體
xy-8165R    RB1CC1RB1的誘導卷曲蛋白RB1CC1抗體
xy-8495R    RNF211環(huán)指蛋白211抗體
xy-8497R    RENBP腎素結(jié)合蛋白抗體
xy-8493R    RFPL2+RFPL3RET指蛋白樣2/3抗體
xy-8496R    RFESDRFESD蛋白抗體
xy-8498R    REG1 beta胰島細胞再生因子β抗體
xy-8376R    RNF160環(huán)指蛋白160抗體
xy-8333R    RDH13視黃醇脫氫酶13抗體
xy-8391R    RNF75環(huán)指蛋白75抗體
xy-8392R    RIT1RIT1蛋白抗體
xy-9246R    RNF19B環(huán)指蛋白19B抗體
xy-8509R    Reg3a胰島β細胞生長因子抗體
xy-9228R    RNF149環(huán)指蛋白149抗體
xy-9230R    RNF158心臟蛋白磷酸酶1結(jié)合蛋白/環(huán)指蛋白158抗體
xy-9233R    RNF180環(huán)指蛋白180抗體
xy-9249R    RNF123環(huán)指蛋白123抗體
xy-8499R    RED軟骨肉瘤相關蛋白2抗體
xy-8494R    RNF210環(huán)指蛋白210抗體
xy-9238R    RNF23環(huán)指蛋白23抗體
xy-9239R    RNF24環(huán)指蛋白24抗體
xy-9240R    RNF25環(huán)指蛋白25抗體
xy-9241R    RNF31環(huán)指蛋白31抗體
xy-9242R    RNF34環(huán)指蛋白34抗體
xy-9244R    RNF21環(huán)指蛋白21抗體
xy-9245R    RNF190環(huán)指蛋白190抗體
xy-11355R    RIC8A膽堿酯酶抑制劑8抗體
xy-11356R    ABCA4神經(jīng)元突觸膜胞外分泌調(diào)節(jié)蛋白1抗體
xy-11357R    RIM2神經(jīng)元突觸膜胞外分泌調(diào)節(jié)蛋白2抗體
xy-9252R    RNF130環(huán)指蛋白130抗體
xy-9609R    RBM26RNA結(jié)合蛋白26抗體
xy-9265R    RNF32環(huán)指蛋白32抗體