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SEMCAP3蛋白抗體

英文名稱 SEMCAP3
中文名稱 SEMCAP3蛋白抗體
別    名 Ligand of Numb protein X 3; likely ortholog of mouse semaF cytoplasmic domain associated protein 3; LNX3; PDZ domain containing ring finger 3; Protein SEMACAP3; SEMACAP3; Semaphorin cytoplasmic domain associated protein; PZRN3_HUMAN.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細胞生物  發(fā)育生物學  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 120kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SEMCAP3/LNX3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
PDZRN3 contains a RING-finger motif in its N-terminal region, two PDZ domains in its central region and a consensus-binding motif for PDZ domains at its C-terminus. It was identified in silico as a homolog of the protein known as LNX1 or SEMCAP1, which possesses ubiquitin ligase activity and binds the membrane protein Semaphorin 4C. However, PDZRN3 itself has not previously been characterized. We have now evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration in vivo were found to be accompanied by up-regulation of PDZRN3. The differentiation-associated increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin.xy-5682R    phospho-RPS6KA1(Ser352)磷酸化絲氨酸/蘇氨酸激酶p90RSK蛋白抗體
xy-5684R    phospho-RAD51(Tyr315)磷酸化Rad51抗體
xy-5685R    phospho-RUNX2(Ser451)磷酸化成骨特異性轉(zhuǎn)錄因子抗體
xy-5689R    phospho-RGS19(Tyr143)磷酸化G蛋白信號轉(zhuǎn)導調(diào)節(jié)因子19抗體
xy-3867R    RGS19G蛋白信號轉(zhuǎn)導調(diào)節(jié)因子19抗體
xy-6142R    RING1環(huán)指蛋白1抗體
xy-4132R    MST1R原癌基因c-Met相關(guān)酪氨酸激酶抗體
xy-5489R    phospho-Ron(Ser1349)磷酸化原癌基因c-Met相關(guān)酪氨酸激酶抗體
xy-5795R    Robo4腫瘤血管內(nèi)皮調(diào)節(jié)蛋白Robo4抗體
xy-5794R    Robo軸突導向受體抗體
xy-1560R    Reelin絡(luò)絲蛋白抗體
xy-13677R    RUSC1RUSC1抗體
xy-13678R    RUSC2RUSC2抗體
xy-13698R    RAGEF2RAGEF2蛋白抗體
xy-12389R    RAB23G蛋白偶聯(lián)受體RAB23抗體
xy-15502R    RGS14 G蛋白信號調(diào)節(jié)因子14抗體
xy-7343R    RANK核轉(zhuǎn)錄因子NF-κB受體/核因子kB受體活化因子抗體
xy-3024R    phospho-RUNX1 (Ser266)磷酸化急性髓細胞白血病1蛋白抗體
xy-9362R    phospho-Proteasome 20S beta 7(Ser214)磷酸化蛋白酶體PSMβ7抗體
xy-3808R    Radixin根蛋白抗體
xy-6887R    Rb2 p130視網(wǎng)膜母細胞瘤樣蛋白2抗體
xy-2802R    RXR gamma維甲酸受體G抗體
xy-13280R    RASA1Rho GTP酶激活蛋白1/血管畸形骨肥大綜合征相關(guān)蛋白抗體
xy-13281R    phospho-RASA1 (Tyr460)磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大綜合征相關(guān)蛋白抗體
xy-9166R    RNF87環(huán)指蛋白87
xy-5330R    Phospho-RhoA(Ser188)磷酸化RhoA蛋白抗體
xy-9180R    RSL1D1細胞衰老抑制基因蛋白抗體
xy-9181R    Repetin中間絲相關(guān)蛋白抗體