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炎癥負(fù)調(diào)控因子蛋白抗體

英文名稱 SELS
中文名稱 炎癥負(fù)調(diào)控因子蛋白抗體
別    名 SELENOS; AD-015; ADO15; MGC104346; MGC2553; SBBI8; SEPS1; VCP-interacting membrane; SELS_HUMAN; Selenoprotein S; SelS; VCP-interacting membrane protein; selenoprotein S; SEPS 1; SELS; VIMP.
   
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 免疫學(xué)  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human selenoprotein S
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.

Subunit:
Interacts with DERL1 and VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm (By similarity).

Similarity:
Belongs to the selenoprotein S family. xy-9260R    RNF170環(huán)指蛋白170抗體
xy-9261R    RNF185環(huán)指蛋白185抗體
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xy-10493R    RPS27ARPS27A抗體
xy-2695R    RANK核轉(zhuǎn)錄因子NF-κB受體抗體(核因子kB受體活化因子)
xy-10076R    ROR alpha維甲酸相關(guān)孤兒受體α抗體
xy-10207R    RSV Nucleoprotein呼吸道合胞病毒核蛋白抗體
xy-3553R    RSK3核糖體蛋白S6激酶家族RSK3抗體
xy-13768R    RCCD1RCCD1蛋白抗體
xy-5654R    phospho-RAD9(Ser328)磷酸化細(xì)胞周期檢查控制蛋白質(zhì)抗體
xy-7726R    phospho-REC8(Ser251)磷酸化減數(shù)分裂重組蛋白家族REC8抗體
xy-8565R    RENT1+hUPF1ATP依賴解旋酶RENT1抗體
xy-6091R    RERGRas相關(guān)雌激素調(diào)節(jié)生長抑制蛋白
xy-6988R    RUBISCO核酮糖1,5二磷酸羧化酶抗體
xy-2744R    RUNX1急性髓細(xì)胞白血病1蛋白抗體
xy-2793R    RET指狀蛋白RET抗體
xy-11393R    RNF39環(huán)指蛋白39抗體
xy-8365R    RAB40BRAS癌基因家族蛋白RAB40B抗體
xy-7075R    phospho-RKIP (Ser153)磷酸化Raf激酶抑制蛋白抗體
xy-7077R    RERE肌萎縮相關(guān)蛋白1抗體
xy-8366R    RAB40ARAS癌基因家族蛋白RAB40A抗體
xy-8367R    RAB40CRAS癌基因家族蛋白RAB40C抗體
xy-11412R    Relaxin 3松弛素3抗體
xy-9578R    Rheumatoid Factor類風(fēng)濕因子抗體
xy-9575R    RPE65視網(wǎng)膜色素上皮細(xì)胞特異性蛋白65抗體
xy-11142R    Rho BRhoB蛋白抗體
xy-11405R    Relaxin 3 receptor 1G蛋白偶聯(lián)受體135/松弛素受體3抗體
xy-11792R    CHEK2絲氨酸蛋白激酶1抗體
xy-9224R    RNF41環(huán)指蛋白41抗體