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膽固醇調(diào)節(jié)元件結(jié)合蛋白1抗體

英文名稱 SREBP1
中文名稱 膽固醇調(diào)節(jié)元件結(jié)合蛋白1抗體
別    名 Sterol regulatory element binding protein 1; ADD 1; BHLHD1; D630008H06; SREBF 1; SREBP-1; SREBF1; SREBP 1; SREBP1; SREBP 1c; Sterol regulatory element binding protein 1; Sterol Regulatory Element Binding Transcription Factor 1 / Protein 1; Sterol regulatory element binding transcription factor 1; SRBP1_HUMAN; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1; Processed sterol regulatory element-binding protein 1.
 
說(shuō) 明 書 0.1ml  0.2ml  
研究領(lǐng)域 心血管  轉(zhuǎn)錄調(diào)節(jié)因子  合成與降解  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54/126kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SREBP-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').

Subunit:
Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA.xy-12373R    STK33絲氨酸/蘇氨酸激酶33抗體
xy-12374R    phospho-STK39(Ser325)磷酸化絲氨酸/蘇氨酸蛋白激酶39抗體
xy-12412R    phospho-SP1 (Thr453)磷酸化轉(zhuǎn)錄生長(zhǎng)因子SP1抗體
xy-12406R    SNX4分選連接蛋白4抗體
xy-12407R    SH3PX1分選連接蛋白9抗體
xy-12408R    SNX10分選連接蛋白10抗體
xy-12409R    SNX11分選連接蛋白11抗體
xy-12410R    SNX6分選連接蛋白6抗體
xy-0493R    SPATA3精子生成相關(guān)蛋白3抗體
xy-12904R    phospho-c-Abl (Ser569)磷酸化非受體酪氨酸激酶c-Abl抗體
xy-13699R    SAM68SRC有絲分裂相關(guān)蛋白68抗體
xy-13700R    SH3BGRL2SH3BGRL2蛋白抗體
xy-13679R    SCLT1鈉離子通道相關(guān)蛋白1抗體
xy-16723R    SH3KBP1SH3結(jié)構(gòu)域激酶結(jié)合蛋白1抗體
xy-13673R    SCAP2Src家族相關(guān)磷酸化蛋白2抗體
xy-13660R    SLAP2SLAP2抗體
xy-13661R    SLP76淋巴細(xì)胞胞漿蛋白2抗體
xy-13662R    phospho-SLP76 (Tyr145)磷酸化淋巴細(xì)胞胞漿蛋白2抗體
xy-13663R    phospho-SLP76 (Tyr113)磷酸化淋巴細(xì)胞胞漿蛋白2抗體
xy-13665R    SOCS7信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子7抗體
xy-13667R    STAP2信號(hào)轉(zhuǎn)導(dǎo)接頭蛋白2抗體
xy-13668R    SLAPSLAP蛋白抗體
xy-2014R    SCP2固醇攜帶蛋白2抗體
xy-13664R    SOCS5信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子5抗體
xy-10415R    SLC4A4碳酸氫鈉協(xié)同轉(zhuǎn)運(yùn)蛋白4-A4抗體
xy-11950R    SHISA9SHISA蛋白家族9抗體
xy-0726R    Survivin細(xì)胞凋亡抑制因子抗體
xy-4101R    Separase外紡錘體極樣蛋白1抗體
xy-1659R    phospho-STAT5a(Tyr694)磷酸化信號(hào)轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子5a抗體