β淀粉樣前體蛋白結(jié)合蛋白2抗體（X11β） 返回列表頁(yè)

英文名稱 APBA2
中文名稱 β淀粉樣前體蛋白結(jié)合蛋白2抗體（X11β）
別    名 Adapter protein X11beta; Amyloid beta A4 precursor protein-binding family A member 2; APBA2; APBA2_HUMAN; D15S1518E; HsT16821; LIN 10; Mint 2; Mint-2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 beta; X11l.
 β淀粉樣前體蛋白結(jié)合蛋白2抗體（X11β）  
說(shuō) 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  Alzheimer's  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human APBA2 (351-450aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 β淀粉樣前體蛋白結(jié)合蛋白2抗體（X11β）產(chǎn)品介紹 background:
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3).

Function:
Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.

Subunit:
Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP.

Tissue Specificity:
Brain.

Similarity:
Contains 2 PDZ (DHR) domains.
Contains 1 PID domain.

Database links:
UniProtKB/Swiss-Prot: Q99767.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 β淀粉樣前體蛋白結(jié)合蛋白2抗體（X11β）xy-12173R KCNF1電壓門控性鉀通道蛋白亞基kv5.1抗體
xy-12174R KCNG1電壓門控性鉀通道蛋白亞基kv6.1抗體
xy-12175R KCNG3電壓門控性鉀通道蛋白亞基KV6.3抗體
xy-12176R phospho-KCNJ1(Ser44)磷酸化細(xì)胞內(nèi)流鉀通道蛋白KCNJ1抗體
xy-12177R KCNT2鈣激活鉀通道蛋白KCNT2抗體
xy-12179R KIR5.1細(xì)胞內(nèi)流鉀通道蛋白Kir5.1抗體
xy-12180R phospho-KIR5.1(Ser416)磷酸化細(xì)胞內(nèi)流鉀通道蛋白Kir5.1抗體
xy-12181R phospho-Kir6.2(Thr224)磷酸化ATP敏感性鉀通道亞基kir6.2抗體
xy-12182R KCNA2B電壓門控鉀通道蛋白KVβ.2抗體
xy-12183R Kv1.4電壓門控性鉀通道蛋白Kv1.4抗體
xy-12184R Kv1.6電壓門控性鉀通道Kv1.6抗體
xy-12185R phospho-Kv2.1(Ser805)磷酸化鉀通道蛋白DRK1抗體
xy-12186R Kv2.2電壓門控性鉀通道Kv2.2抗體
xy-11211R KIF3A驅(qū)動(dòng)蛋白家族蛋白3抗體
xy-11212R KLC1驅(qū)動(dòng)蛋白2抗體
xy-8563R KIAA1522KIAA1522蛋白抗體
xy-9431R KCTD5鉀離子通道四聚體結(jié)構(gòu)域蛋白5抗體
xy-9504R KLMW Kininogen高分子量激肽原重鏈抗體
xy-9637R KCTD11鉀通道四聚體結(jié)構(gòu)域蛋白11抗體
xy-8052R KLHL26Kelch樣蛋白26抗體
xy-6940R KDEL (ER Marker)賴氨酸，天冬氨酸，谷氨酸，亮氨酸相關(guān)序列抗體
xy-8054R KLHL10Kelch樣蛋白10抗體
xy-8055R KLHL11Kelch樣蛋白11抗體
xy-8053R KLHL3Kelch樣蛋白3抗體
xy-8056R KLHL14Kelch樣蛋白14抗體
xy-8057R KLHL31Kelch樣蛋白31抗體
xy-8058R KLHL32Kelch樣蛋白32抗體