ASCL2蛋白抗體 返回列表頁

英文名稱 ASCL2
中文名稱 ASCL2蛋白抗體
別    名 Achaete scute complex like 2; Achaete scute homolog 2; achaete-scute complex-like 2; Achaete-scute homolog 2; ASCL2; ASCL2_HUMAN; ASH-2; Ash2; bHLHa45; Class A basic helix-loop-helix protein 45; HASH2; Mash2.
ASCL2蛋白抗體   
說 明 書 0.1ml  0.2ml  
研究領域 細胞生物  發(fā)育生物學  信號轉導  干細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from Human ASCL2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes, both of which work together to activate DNA transcription. Class A proteins include the ubiquitously expressed E-box binding factors, namely E2A, ITF-2 and HEB, while class B proteins, such as MyoD, myogenin and Neuro D (BETA2), are transiently expressed and exhibit a much more limited tissue distribution. Working in opposition to these positively acting factors are a specialized group of basic helix-loop-helix (bHLH) transcription factors that function as dominant negative regulators and are involved in cell lineage determination and differentiation. ASCL2 is a 193 amino acid protein that localizes to the nucleus and contains one bHLH domain. Expressed in developing placental tissue, ASCL2 binds to DNA and functions as a transcriptional regulator that is involved in the maturation of neuronal precursors in the peripheral and central nervous systems.

Function:
AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed specifically in the extravillous trophoblasts of the developing placenta.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

Gene ID:
430

Database links:

Entrez Gene: 430 Human

Entrez Gene: 17173 Mouse

Entrez Gene: 24209 Rat

SwissProt: Q99929 Human

SwissProt: O35885 Mouse

SwissProt: P19360 Rat

Unigene: 152475 Human

Unigene: 196417 Mouse

Unigene: 10486 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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