腺瘤性結腸息肉病蛋白2抗體 返回列表頁

英文名稱 APC2
中文名稱 腺瘤性結腸息肉病蛋白2抗體
別    名 Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APCL; APC2_HUMAN.
腺瘤性結腸息肉病蛋白2抗體   
說 明 書 0.1ml  0.2ml  
研究領域 腫瘤  免疫學  細胞粘附分子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Horse, 
產品應用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 244kDa
細胞定位 細胞漿 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human APCL/APC2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner’s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin.

Function:
APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor.

Subunit:
Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2.

Subcellular Location:
Cell Membrane, Cytoplasmic and Golgi Apparatus

Tissue Specificity:
Widely expressed (at protein level). Specifically expressed in the CNS.

Similarity:
Belongs to the adenomatous polyposis coli (APC) family.
Contains 6 ARM repeats.

Gene ID:
29882

Database links:

Entrez Gene: 29882 Human

Entrez Gene: 99152 Mouse

Entrez Gene: 296558 Rat

Omim: 606946 Human

SwissProt: Q9UJX6 Human

SwissProt: Q8BZQ7 Mouse

Unigene: 434898 Human

Unigene: 533262 Human

Unigene: 291624 Mouse

Important Note:
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