蛋白激酶錨定蛋白13抗體 返回列表頁

英文名稱 AKAP13
中文名稱 蛋白激酶錨定蛋白13抗體
別    名 A kinase (PRKA) anchor protein 13; A kinase anchor protein 13; A kinase anchoring protein; A-kinase anchor protein 13; AKAP 13; AKAP Lbc; AKAP-13; AKAP-Lbc; AKAP13; AKP13_HUMAN; ARHGEF13; Breast cancer nuclear receptor binding auxiliary protein; Breast cancer nuclear receptor-binding auxiliary protein; BRX; c lbc; FLJ11952; FLJ43341; Guanine nucleotide exchange factor Lbc; HA 3; HA3; Ht 31; Ht31; Human thyroid anchoring protein 31; Human thyroid-anchoring protein 31; LBC; LBC oncogene; Lymphoid blast crisis oncogene; Non oncogenic Rho GTPase specific GTP exchange factor; Non-oncogenic Rho GTPase-specific GTP exchange factor; P47; Protein kinase A anchoring protein 13; Protein kinase A-anchoring protein 13; PROTO LB; PROTO LBC.
蛋白激酶錨定蛋白13抗體    
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  激酶和磷酸酶  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Horse, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 307kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AKAP13
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions.

Subcellular Location:
Cytoplasm; Cytoplasm. Nucleus and Membrane.

Tissue Specificity:
Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver, pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver.

Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.


Gene ID:
11214

Database links:

Entrez Gene: 11214 Human

Omim: 604686 Human

SwissProt: Q12802 Human

Unigene: 459211 Human

Unigene: 710656 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xy-9232R RNF167環(huán)指蛋白167抗體
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