Apollon凋亡抑制蛋白抗體 返回列表頁(yè)

英文名稱 BIRC6
中文名稱 Apollon凋亡抑制蛋白抗體
別    名 BIRC6; Apollon; Apollon protein; Baculoviral IAP repeat containing 6; Baculoviral IAP repeat containing protein 6; BIRC 6; BRUCE; FLJ13726; FLJ13786; KIAA1289; Ubiquitin conjugating BIR domain enzyme apollon; BIRC6_HUMAN.
 Apollon凋亡抑制蛋白抗體    
說(shuō) 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  細(xì)胞凋亡  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 530kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Apollon C terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 產(chǎn)品介紹 background:
Conserved genes that encode inhibitors of apoptosis proteins (IAPs) are frequently overexpressed in human cancers and are associated with resistance to therapy. IAPs contain a 70 amino acid cysteine and histidine rich baculovirus IAP repeat (BIR) and often a zinc binding RING finger. Chen et al. (1999) found that some brain cancer cell lines with high expression of BIRC6 exhibited resistance to apoptosis in the presence of anticancer drugs. Treatment of a high expressing cell line with BIRC6 antisense oligonucleotides reduced BIRC6 expression and reversed the resistance to anticancer drugs.

Function:
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

Subunit:
Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8.

Subcellular Location:
Golgi apparatus, trans-Golgi network membrane. Midbody. Endosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, centrosome. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in ophase and during cytokinesis.

Tissue Specificity:
Expressed in brain cancer cells.

Post-translational modifications:
Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.

Similarity:
In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.
Contains 1 BIR repeat.

Database links:

Entrez Gene: 57448 Human

Entrez Gene: 12211 Mouse

Omim: 605638 Human

SwissProt: Q9NR09 Human

SwissProt: O88738 Mouse

Unigene: 150107 Human

Unigene: 290908 Mouse

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