Bcl-xL蛋白抗體 返回列表頁(yè)

英文名稱(chēng) Bcl-xL
中文名稱(chēng) Bcl-xL蛋白抗體
別    名 Apoptosis regulator Bcl X; BclX; Bcl-X; Bcl 2 like 1; Bcl 2 like 1 protein; Bcl xL; BCL X/L; BCL XL/S; Bcl xS; Bcl2 like1; BCL2-related gene; BCL2-related protein, long isoform, included; BCLXL, included; BCL2-related protein, short isoform, included; BCLXS, included; BCL2L; BCL2L1; Bclx; DKFZp781P2092; MGC113803; MGC99998; B2CL1_HUMAN.
Bcl-xL蛋白抗體
    
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  線粒體  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 線粒體
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Bcl-xL
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008].

Function:
Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Isoform Bcl-X(S) promotes apoptosis.

Subunit:
Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with DMN1L; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters. Interacts with BAD and BBC3. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Interacts (isoform Bcl-X(L)) with BAX (isoform Sigma). Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2.

Subcellular Location:
Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, centrosome. Note=Mitochondrial membranes and perinuclear envelope. Localizes to the centrosome when phosphorylated at Ser-49.

Tissue Specificity:
Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Post-translational modifications:
Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during ophase and cytokinesis.

Similarity:
Belongs to the Bcl-2 family.

Gene ID:
598

Database links:

Entrez Gene: 598 Human

Entrez Gene: 12048 Mouse

Entrez Gene: 24888 Rat

Omim: 600039 Human

SwissProt: Q07817 Human

SwissProt: Q64373 Mouse

SwissProt: P53563 Rat

Unigene: 516966 Human

Unigene: 238213 Mouse

Unigene: 10323 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
xy-4733R ABP1植物生長(zhǎng)激素ABP1抗體
xy-8450R phospho-ATF2 (Thr55)磷酸化活化復(fù)制因子2抗體
xy-10465R ADRA1Balpha 1腎上腺素能受體B抗體
xy-15533R Bcl-2 alphaBcl2 alpha蛋白抗體
xy-9757R BAT5白細(xì)胞抗原B相關(guān)轉(zhuǎn)錄蛋白5抗體
xy-9294R BTBD1BTB/POZ結(jié)構(gòu)域蛋白1（丙型肝炎病毒的NS5A反轉(zhuǎn)錄蛋白8）抗體
xy-9298R BCL7BBCL7B蛋白抗體
xy-9293R BNC2堿性核蛋白2(鋅指蛋白basonuclin2)抗體
xy-9763R BCL7CB細(xì)胞白血病/淋巴瘤蛋白7抗體
xy-6311R BSCL2先天性脂肪代謝障礙蛋白2抗體（常染色體顯性遺傳痙攣性截癱17）
xy-7526R BTG1B細(xì)胞遷移基因1抗體
xy-11710R BEAN1脊髓小腦共濟(jì)失調(diào)蛋白BEAN1抗體
xy-12559R B7-H6B7H6蛋白抗體
xy-1418R BOb-1B細(xì)胞特異性轉(zhuǎn)錄因子抗體
xy-1485R BIN1橋連整合因子蛋白抗體
xy-0612R BADH2BADH2抗體(水稻)
xym-2011M BCHE(1E8)丁酰膽堿酯酶單克隆抗體
xy-2063R phospho-beta catenin (Tyr142)磷酸化β 連環(huán)素蛋白抗體
xy-2065R Beta-lactoglobulinβ-乳球蛋白抗體
xy-2064R Beta-lactoglobulinβ-乳球蛋白抗體
xy-2422R BDKRB2緩激肽B2受體抗體
xy-0986R Butyrylcholinesterase (NT)丁酰膽堿酯酶抗體(N端)
xy-0987R BCHE (CT)丁酰膽堿酯酶抗體(C端)
xy-2473R BLAMEBLAME抗體
xym-0910M Batroxobin(5H4)巴曲霉毒素單克隆抗體
xy-0911R Batroxobin蛇毒巴曲酶抗體