細(xì)胞表面趨化因子受體6抗體 返回列表頁

英文名稱 BONZO
中文名稱 細(xì)胞表面趨化因子受體6抗體
別    名 CXC-chemokine receptor 6; C X C chemokine receptor type 6; CD 186; CD186; CD186 antigen; CDw186; Chemokine (C X C motif) receptor 6; Chemokine C X C motif receptor 6; Chemokine C-X-C Motif Receptor 6; Chemokine CXC motif receptor 6; Chemokine receptor 6; CXC chemokine receptor type 6; CXC R6; CXCR 6; CXCR6; G protein coupled receptor; G protein coupled receptor bonzo; G protein coupled receptor STRL 33; G protein coupled receptor STRL33; G protein coupled receptor TYMSTR; STRL 33; STRL33; TYMSTR; CXCR6_HUMAN; CXC-R6.
細(xì)胞表面趨化因子受體6抗體 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞膜受體  G蛋白偶聯(lián)受體  細(xì)胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CXCR6
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

產(chǎn)品介紹 background:
Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) require coreceptors to enter and infect target cells. They are dependent upon an interaction between the viral envelope glycoprotein with T cell antigen T4 (CD4) and a G protein coupled receptor (GPCR). HIV1 infection relies upon interaction with a chemokine receptor, usually chemokine (C-C) receptor 5 (CCR5). During progression of the infection, the virus tends to rely upon chemokine (C-X-C) receptor 4 (CXCR4). SIV also utilizes CCR5 in the early stages of infection, but during progression it tends to rely on two orphan GPCR's named chemokine (C-X-C) receptor 6 (Bonzo) and G protein coupled receptor 15 (BOB/GRP15). Bonzo mRNA expression has been localized to lymphoid tissues and activated peripheral blood lymphocytes.

Function:
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in lymphoid tissues and activated T cells.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Gene ID:
10663

Database links:

Entrez Gene: 10663 Human

Omim: 605163 Human

SwissProt: O00574 Human

Unigene: 34526 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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