骨涎蛋白抗體 返回列表頁(yè)

英文名稱 Bone sialoprotein
中文名稱 骨涎蛋白抗體
別    名 BNSP; Bone sialoprotein II; BSP; BSPII; Cell binding sialoprotein; Integrin binding sialoprotein; SPII; SIAL_HUMAN; Bone sialoprotein 2; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein.
骨涎蛋白抗體   
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 生長(zhǎng)因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
細(xì)胞定位 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Bone sialoprotein II
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximay 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]

Function:
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Subcellular Location:
Secreted.

Post-translational modifications:
N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains.
Sulfated on either Tyr-320 or Tyr-321 (By similarity).

Gene ID:
3381

Database links:

Entrez Gene: 3381 Human

Entrez Gene: 15891 Mouse

Entrez Gene: 24477 Rat

Omim: 147563 Human

SwissProt: P21815 Human

SwissProt: Q61711 Mouse

SwissProt: P13839 Rat

Unigene: 518726 Human

Unigene: 4987 Mouse

Unigene: 9721 Rat

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