信號(hào)調(diào)節(jié)蛋白α抗體 返回列表頁(yè)

英文名稱 SIRP Alpha
中文名稱 信號(hào)調(diào)節(jié)蛋白α抗體
別    名 Signal regulatory protein alpha type 1; BIT; Brain Ig like molecule with tyrosine based activation motifs; Brain immunoglobulin like molecule with tyrosine based activation motifs; CD172 antigen like family member A; CD172a; CD172a antigen; Inhibitory receptor SHPS1; Macrophage fusion receptor; MFR; MYD 1; Myd 1; MYD1; p84;Protein tyrosine phosphatase non receptor type substrate 1; PTPNS1; SHP Substrate 1; SHPS1; Signal regulatory protein alpha 2; Signal regulatory protein alpha 3; Signal regulatory protein alpha; Signal Regulatory Protein Alpha Type 1; Signal regulatory protein alpha type 2; SIRP; SIRPA; SIRPalpha; SIRPalpha1; SIRPalpha2; SIRPalpha3; Tyrosine phosphatase SHP substrate 1; Tyrosine protein phosphatase non receptor type substrate 1; Tyrosine protein phosphatase non receptor type substrate; CD172a.
信號(hào)調(diào)節(jié)蛋白α抗體
說(shuō) 明 書 0.2ml  
研究領(lǐng)域 神經(jīng)生物學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD172a
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
信號(hào)調(diào)節(jié)蛋白α抗體產(chǎn)品介紹 background:
Protein tyrosine phosphatases (PTPases) SHP1 and SHP2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1),SHPS1 , MyD1, BIT and p84. SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP2. SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.

Function:
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Subunit:
Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.

Subcellular Location:
Membrane; Single-pass type I membraneprotein.

Tissue Specificity:
Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

Post-translational modifications:
N-glycosylated.
Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF.
Dephosphorylated by PTPN11.

Similarity:
Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Gene ID:
140885

Database links:

Entrez Gene: 140885 Human

Entrez Gene: 19261 Mouse

Entrez Gene: 25528 Rat

Omim: 602461 Human

SwissProt: P78324 Human

SwissProt: P97797 Mouse

SwissProt: P97710 Rat

Unigene: 581021 Human

Unigene: 1682 Mouse

Unigene: 53971 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.信號(hào)調(diào)節(jié)蛋白α抗體xy-13867R CES1P1CES1P1蛋白抗體
xy-13868R CES2羧酸酯酶2抗體
xy-13869R CES3羧酸酯酶3抗體
xy-13870R CES4A羧酸酯酶4A抗體
xy-13871R CES6羧酸酯酶6抗體
xy-13872R CezanneCezanne蛋白抗體
xy-13873R CFC1內(nèi)臟移位線管蛋白CFC1蛋白抗體
xy-13874R CFHL2補(bǔ)體因子H相關(guān)蛋白2抗體
xy-13875R CFHL4補(bǔ)體因子H相關(guān)蛋白4抗體
xy-13876R CFHL5補(bǔ)體因子H相關(guān)蛋白5抗體
xy-13877R CG028/C7orf28A7號(hào)染色體開(kāi)放閱讀框28A抗體
xy-13878R CGBPCpG結(jié)合蛋白抗體
xy-13879R CGGBP1CGG結(jié)合蛋白1抗體
xy-13880R CGK2cGMP依賴性蛋白激酶2抗體
xy-13881R CGNL1結(jié)蛋白樣蛋白CGNL1抗體
xy-13882R CGREF1細(xì)胞生長(zhǎng)調(diào)節(jié)蛋白CGREF1抗體
xy-13884R CHAD富含亮氨酸軟骨蛋白抗體
xy-13885R CHADL軟骨蛋白樣蛋白抗體
xy-13887R CHCHD3卷曲螺旋結(jié)構(gòu)域蛋白CHCHD3抗體
xy-13888R CHCHD10卷曲螺旋結(jié)構(gòu)域蛋白CHCHD10抗體
xy-13889R CHCHD7卷曲螺旋結(jié)構(gòu)域蛋白CHCHD7抗體
xy-18890R CHD1ATP依賴的解旋酶CHD1抗體
xy-18891R CHD1L染色質(zhì)解旋酶DNA結(jié)合蛋白抗體
xy-13892R CHD2染色質(zhì)解旋酶DNA結(jié)合蛋白2抗體
xy-18893R CHD3染色質(zhì)解旋酶DNA結(jié)合蛋白3抗體
xy-13893R CHD4染色質(zhì)解旋酶DNA結(jié)合蛋白Mi2β抗體
xy-13894R CHD6ATP依賴的解旋酶CHD6抗體
xy-13895R CHD7ATP依賴的解旋酶CHD7抗體