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Integrin beta 1 (ITGB1) 抗體

抗原
Integrin beta 1 (ITGB1)
別名 cd29, fnrb, gpiia, itgb1, mdf2, msk12, vla-beta, vlab, CD29, 4633401G24Rik, AA409975, AA960159, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
適用
其他選擇 Human, Pig (Porcine), Dog (Canine)
Human(280),Murine (116),Rat (Rattus) (76),Dog (Canine) (29),Pig (Porcine) (24),Chicken (12),Bovine (12),Monkey (8),Zebrafish (6),Rabbit (1)
宿主
其他選擇 Mouse
Mouse(175),Rabbit (120),Hamster (45),Rat (5),Chicken (3)
克隆類型 (克隆位點(diǎn))
Monoclonal (MEM-101A)
標(biāo)記
其他選擇 PE
PE(31),FITC (27),Biotin (23),APC (12),HRP (3),Cy7,PE (2),PE,Cy7 (2),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),PE-Dyomics 647 (1)
應(yīng)用范圍
其他選擇 Flow Cytometry (FACS)
Western Blotting (WB)(181),Flow Cytometry (FACS) (179),ELISA (116),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (62),Immunoprecipitation (IP) (55),Immunohistochemistry (IHC) (45),Immunohistochemistry (Frozen Sections) (IHC (fro)) (41),Immunofluorescence (IF) (30),Immunocytochemistry (ICC) (20),Functional Studies (Func) (10),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (9),Enzyme Immunoassay (EIA) (3),Fluorescence Microscopy (FM) (2),Blocking Antibody (Inhibition) (1),Immunoassay (IA) (1),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (1),Immunohistochemistry (Paraformaldehyde) (IHC (pfa)) (1)
[Pubmed] 8 references available
規(guī)格 100 tests
發(fā)貨至 中國(guó) (Change)
發(fā)貨時(shí)間 23至29個(gè)工作日

Integrin beta 1 (ITGB1) 抗體

產(chǎn)品細(xì)節(jié)

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免疫原 Raji Burkitt's lymphoma cell line
克隆位點(diǎn) MEM-101A
亞型 IgG1
特異性 The antibody MEM-101A reacts with CD29 (integrin beta1 chain), a 130 kDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 is broadly expressed on majority of hematopoietic and non-hematopoietic cells (leukocytes, plaets, fibroblasts, endothelial cells, epithelial cells and mast cells).HLDA VI, WS Code AS A048
無(wú)交叉反應(yīng) Murine
產(chǎn)品特性 The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.

目標(biāo)詳細(xì)情況

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Integrin beta 1 (ITGB1) 抗體目標(biāo)詳細(xì)情況

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別名 ITGB1
背景 CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In plaets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.

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使用細(xì)節(jié)

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應(yīng)用備注 The reagent is designed for Flow Cytometry analysis of human blood cells using 20 µL reagent / 100 µL of whole blood or 10^6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Working concentrations should be determined by the investigator.
限制 For Research Use only

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溶解方式 No reconstitution is necessary.
緩沖液 The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
儲(chǔ)存液 Sodium azide
Integrin beta 1 (ITGB1) 抗體注意事項(xiàng) WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediay. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
注意事項(xiàng) Do not freeze.
Avoid prolonged exposure to light.
儲(chǔ)存條件 4 °C
儲(chǔ)存方法 Store in the dark at 2-8 °C. Do not use after expiration date stamped on vial label. Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.xy-3569R AP2 alpha轉(zhuǎn)錄激活蛋白2α/TFAP2α/AP-2α抗體
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