CD3 （CD3） 抗體 （PE） 返回列表頁

CD3 (CD3) 抗體 (PE)

抗原
CD3 (CD3)
別名 CD3
適用
 其他選擇Murine
宿主
 其他選擇Rat
克隆類型 (克隆位點)
單克隆 (KT3)
標記
 其他選擇PE
應(yīng)用范圍
 其他選擇Flow Cytometry (FACS)
[Pubmed] 8 references available
規(guī)格 100 tests
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

CD3 (CD3) 抗體 (PE)

產(chǎn)品細節(jié)

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免疫原 Spleen cells from immunised SD rats were fused with cells of the NSO mouse myeloma cell line.
克隆位點 KT3
亞型 IgG2a
特異性 This antibody recognises the CD3 antigen which is expressed by mature T cells.
純化方法 Affinity Chromatography on Protein A

目標詳細情況

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別名 CD3
背景 Cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82?% of normal peripheral blood lymphocytes, 65-85?% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.Synonyms: T-cell surface antigen T3/Leu-4, T-cell surface glycoprotein CD3, T3/Leu-4
基因ID 12501
NCBI Accession NP_031674
UniProt P22646
研究領(lǐng)域 Immunology, Adaptive Immunity, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells

CD3 (CD3) 抗體 (PE)使用細節(jié)

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應(yīng)用備注 Flow Cytometry: use 10 μL of neat antibody to label 10^6 cells. For optimal stainingincubations should be performed at room temperature, The Fc region of monoclonalantibodies may bind non-specifically to cells expressing low affinity Fc receptors. 
Other applications not tested. 
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

CD3 (CD3) 抗體 (PE)貯存及處理

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溶解方式 Restore with 1.0?mL distilled water.
緩沖液 PBS,?pH 7.4, 0.09?% Sodium Azide, 5?% Sucrose, 1?% BSA
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項 Dilute only prior to immediate use
儲存條件 4 °C
儲存方法 Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.

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