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當(dāng)前位置:上海信裕生物科技有限公司>>抗體>>一抗>> EBI3抗體
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更新時(shí)間:2018-01-08 15:00:25瀏覽次數(shù):922次
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抗原
Epstein-Barr Virus Induced 3 (EBI3)
別名 IL-27B, IL27B, EBI-3, IL-27
適用
其他選擇 Murine
Murine(72),Human (69),Rat ((Rattus)) (29),Bovine (13),Pig (Porcine) (13),Dog (Canine) (12),Horse (Equine) (1),Monkey (1)
宿主
其他選擇 Mouse
Rabbit(72),Mouse (20),Rat (16),Goat (4)
克隆類型 (克隆位點(diǎn))
單克隆 (V1.4H6.29)
標(biāo)記
其他選擇 非結(jié)合性
Biotin(13),HRP (4),FITC (3),APC (1),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),PE (1)
應(yīng)用范圍
其他選擇 Western Blotting (WB), ELISA, Immunoprecipitation (IP)
Western Blotting (WB)(92),ELISA (65),Immunohistochemistry (IHC) (26),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (16),Flow Cytometry (FACS) (14),Immunoprecipitation (IP) (14),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Neutralization (Neut) (10),Immunocytochemistry (ICC) (4),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (3),Immunohistochemistry (Frozen Sections) (IHC (fro)) (3),Enzyme Immunoassay (EIA) (2),Functional Studies (Func) (2),Immunofluorescence (IF) (1)
[Pubmed] 1 reference available
規(guī)格 25 μL
發(fā)貨至 中國 (更改)
EBI3抗體
產(chǎn)品細(xì)節(jié)
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產(chǎn)品細(xì)節(jié)
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免疫原 Anti-EBI-3 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with mature full length recombinant mouse EBI-3 produced in E.coli followed by hybridoma development.
Immunogen Type: RecombinantProtein
克隆位點(diǎn) V1.4H6.29
亞型 IgG2b
特異性 Anti-EBI-3 was purified from mouse ascites by Protein A chromatography followed by extensive dialysis against the buffer stated above. This antibody is specific for mouse EBI3 protein. A BLAST analysis was used to suggest cross-reactivity with EBI3 from mouse sources based on 100% homology with the immunizing sequence. Cross-reactivity with EBI-3 from other sources has not been determined.
產(chǎn)品特性 The cytokine Interleukin 27 (IL-27) is produced in response to inflammation. It is made by activated antigen presenting cells including monocytes, endothelial cells, and dendritic cells. IL-27 consists of a heterodimeric combination of Epstein-Barr virus-induced molecule 3 (EBI3, or IL-27B) non-covalently linked with IL-27 p28 (or IL-27A). It is a regulator of T helper cell development and suppressor of T-cell proliferation. IL-27 has both pro- and anti-inflammatory properties. It can stimulate cytotoxic T cell activity and induce isotype switching in B-cells. It has diverse effects on innate immune cells. It induces monocytes and mast cells to secrete pro-inflammatory cytokines. When infection is present, IL-27 induces naive CD4+ T cells to proliferate and develop Th1 cell responses. As an anti-inflammatory regulator, IL-27 can inhibit Th1 or Th2 responses and restrict the strength and duration of adaptive immune responses. The IL-27 p28 subunit, a 28 kDa glycoprotein belonging to the type I cytokine family, is homologous to IL-12 p35, IL-23 p19, and IL-6. The EBI3 (Epstein-Barr virus-induced molecule 3, or IL-27B) subunit is a 34 kDa glycoprotein containing two fibronectin type III domains, and belongs to the type I cytokine receptor family. It can exist as a homodimer and can also heterodimerize with IL-27 p28 or IL-12 p35 subunit. It is homologous to the p40 subunit of IL-12 and IL-23 and to the extracellular domain of IL-6 R.
過濾 Sterile filtered
目標(biāo)詳細(xì)情況
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目標(biāo)詳細(xì)情況
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別名 EBI-3
背景 The cytokine Interleukin 27 (IL-27) is produced in response to inflammation. It is made by activated antigen presenting cells including monocytes, endothelial cells, and dendritic cells. IL-27 consists of a heterodimeric combination of Epstein-Barr virus-induced molecule 3 (EBI3, or IL-27B) non-covalently linked with IL-27 p28 (or IL-27A). It is a regulator of T helper cell development and suppressor of T-cell proliferation. IL-27 has both pro- and anti-inflammatory properties. It can stimulate cytotoxic T cell activity and induce isotype switching in B-cells. It has diverse effects on innate immune cells. It induces monocytes and mast cells to secrete pro-inflammatory cytokines. When infection is present, IL-27 induces naive CD4+ T cells to proliferate and develop Th1 cell responses. As an anti-inflammatory regulator, IL-27 can inhibit Th1 or Th2 responses and restrict the strength and duration of adaptive immune responses. The IL-27 p28 subunit, a 28 kDa glycoprotein belonging to the type I cytokine family, is homologous to IL-12 p35, IL-23 p19, and IL-6. The EBI3 (Epstein-Barr virus-induced molecule 3, or IL-27B) subunit is a 34 kDa glycoprotein containing two fibronectin type III domains, and belongs to the type I cytokine receptor family. It can exist as a homodimer and can also heterodimerize with IL-27 p28 or IL-12 p35 subunit. It is homologous to the p40 subunit of IL-12 and IL-23 and to the extracellular domain of IL-6 R.
Synonyms: Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein
基因ID 50498
NCBI Accession NP_056581
UniProt O35228
使用細(xì)節(jié)
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使用細(xì)節(jié)
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應(yīng)用備注 EBI-3 antibody has been tested for use in ELISA, IP, and Western Blot. Specific conditions for reactivity should be optimized by the end user.
說明
Gene Name: EBI3
限制 For Research Use only
貯存及處理
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貯存及處理
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狀態(tài) Liquid
濃度 1.0 mg/mL
緩沖液 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
儲(chǔ)存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
儲(chǔ)存條件 4 °C/-20 °C
儲(chǔ)存方法 Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not compley clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
有效期 12 months
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